ArticleSYNTHESIS OF NOVEL 4-(5-PHENYL-4, 5 DIHYDRO-1H-PYRAZOL-3-YL AMINO) PHENOL DERIVATIVES AND EVALUATION OF THEIR ANTI DEPRESSANT PROPERTIES
Sashmitha Samuel B* , Dr. K. S. Murali Krishna
Sashmitha Samuel B*
Depression is a prevalent psychiatric disorder with estimates reaching as high as 21% of the world population. It is a chronic illness that affects a person’s mood, thoughts, physical health and behavior. Symptoms of depression include biological and emotional components. Biological symptoms include retardation of thought, action and appetite. Emotional symptoms include mystery, apathy and pessimism, low self-esteem consisting of feeling of guilt, inadequancy and ugliness, indecisiveness and loss of motivation. In an attempt to synthesize and evaluate new compounds as antidepressants, we report, herein, synthesis and biological evaluation of a number of pyrazoline derivatives namely 4-(5-phenyl-4, 5 dihydro-1Hpyrazol- 3-yl amino) phenols. The title compounds were synthesized by a very novel route involving the reaction of p-hydroxy phenyl acetamide with various aromatic aldehydes. All the derivatives were obtained in good yields and almost all the compounds have proved to be potent anti-depressants as compared to Fluoxetine.
Depression, Novel Pyrazoline Derivatives, Fluoxetine, Tail Suspension test.