ArticleFORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL PHOSPHATE USING VARIOUS BRANDS OF XANTHAN GUM
Jayapal Nallapu * , Swathi Baswa, Vamshi Vishnu Yamsani
Jayapal Nallapu *
Present investigation is to formulate sustained release Carvedilol Phosphate tablets, an anti-hypertensive agent by wet granulation technique using microcrystalline cellulose as diluent. Twelve formulations of sustained release tablets of Carvedilol Phosphate were prepared using Xantural 75, Ziboxan PM200 and Xanthan 1L4172K as release retarding agents in different concentrations of 5, 10, 15% w/w. The prepared batches evaluated for organoleptic properties, hardness, friability, weight variation and in vitro release. All formulations showed low weight variation with rapid dispersion time and rapid in vitro dissolution. One amongst twelve promising formulations, the formulation prepared using 5%w/w of Xantural 75 emerged as optimized formulation. All formulations complied with the quality control standards for weight variation, drug content, hardness and friability. Results of the present study demonstrated that hydrophilic polymers xantural 75, ziboxan PM 200 and Xanthan 1L4172K could be successfully employed for formulating sustained-release matrix tablets of Carvedilol phosphate. Once a day tablets taken orally can be formulated using these polymers. All formulations tested for powder characterization and physical evaluation parameters were within limits. drug release from all the matrix tablets showed polymer dependent sustaining effect. Optimized formulation F1 which includes Xantural 75 has successfully sustained the drug release for 24 hours and the drug release pattern was not similar to marketed release profile. F1 formulation showed more sustained drug release upto 24 hrs than marketed tablet (Cardivas). Xantural 75 containing formulation showed sustained release with 5% ,it would reduce the cost of the tablets.
Xantural 75, Carvedilol Phosphate, Sustained release.