Article

DESIGN, SYNTHESIS AND BIOLOGICAL CHARACTERIZATION OF 2-SUBSTITUTED THAIZOLIDINE DERIVATIVES
Gayam Krishna Reddy* , Senthilkumar Palaniappan

Details

Author

Gayam Krishna Reddy*

ISSN

Applied

DOI

https://doi.org/10.5281/zenodo.3383851

Published on

Aug 24, 2019

Abstract

A series of N-((4,5-dihydro-5-substituted-1-thiocarbamoyl-1-H-pyrazol-3-ylamino)(methylthio)methyl)-2-substituted thiazolidine-4-carboxamide derivative were synthesized. The synthesized compounds were characterized by IR, NMR, and Mass spectral data. The synthesized compounds were screened for their antibacterial and antifungal activity against pathogenic bacteria and fungi. Compounds TP-17, N-((4,5-dihydro-5-(4-methoxyphenyl)-1-thiocarbamoyl-1-H-pyrazol-3-ylamino) (methylthio) methyl) -2- methoxythiazolidine-4-carboxamide and TP-22, N-((4,5-dihydro-5-(4-chlorophenyl)-1-thiocarbamoyl-1-H-pyrazol-3-ylamino) (methylthio)methyl)-2-methoxy thiazolidine-4-carboxamide exhibited good antibacterial and antifungal activity against the tested microorganisms.

Keywords

Substituted thiazolidine, Minimum Inhibitory Concentration, Antifungal and Antibacterial

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