ArticleFORMULATION AND EVALUATION OF COLON TARGETED SULFASALAZINE MICROSPHERES
Diksha Saitwal , Dr Surajj Sarode, Dr. S.D. Barhate
Sulfasalazine is an anti-inflammatory drug used in the treatment of ulcerative colitis. It is metabolised in colon by the bacterial enzyme azoreductase to sulfapyridine and 5-amino salicylic acid. It is rapidly absorbed in the intestine, hence it is necessary to develop colon targeted drug delivery system. Sulfasalazine releases 5-ASA which decreases the inflammation of intestine & thus helpful in ulcerative colitis. The main objective of the present research is formulated and evaluated colon targeted sulfasalazine microspheres by emulsion solvent evaporation method by using 2-factor central composite design. Optimized formulation S2 showed highest drug release (92.36%) at the end of 12 hours, maximum entrapment efficiency (91.27%) and particle size was in acceptable range (64.1 to 74.5 µm) at medium level of concentration of eudragit s 100 (1000mg) and concentration of span 80 (1%). FT-IR and DSC study indicates that drug is compatible with excipients and there is no interaction between them. The release kinetics of optimized formulation shows first order release followed by non-fickian diffusion.
Emulsion solvent evaporation method, Sulfasalazine, Microspheres, Eudragit S100 and Span 80