A simple, Accurate, precise method was developed for the simultaneous estimation of the Meropenem and Vaborbactam in tablet dosage form. Chromatogram was run through SB C8 100 x 3.0 mm, 1.8m. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: acetonitrile taken in the ratio 60:40v/v was pumped through column at a flow rate of 0.3 ml/min.. Temperature was maintained at 30°C. Optimized wavelength selected was 260 nm. Retention time of meropenem and vaborbactam were found to be 1.190 min and 1.639 min. %Recovery was obtained as 99.86% and 99.61% for meropenem and vaborbactam respectively. LOD, LOQ values obtained from regression equations of meropenem and vaborbactam were 0.11, 0.34 and 0.70, 2.13 respectively. Regression equation of meropenem is y = 9265.x + 13267, and = 9295.x + 12348 of vaborbactam.